Staples, Inc. is an American multinational office supply retailing corporation, with over 1,500 stores in North America. Headquartered in Framingham, Massachusetts, Staples also does business extensively with enterprises in the United States and Canada, and as Staples Business AdvantageStaples, Inc. is an American multinational office supply retailing corporation, with over 1,500 stores in North America. Headquartered in Framingham, Massachusetts, Staples also does business extensively with enterprises in the United States and Canada, and as Staples Business Advantage